Last time I had a machine running CentOS (6.2 iirc) I had managed to get a big yellow arrow to show the mouse cursor. It was wonderful.
Now I have machines running Fedora (17 & 18) and Puppy (5.0)
If you are using KDE 4.x then goto System Settings -> Workspace Decorations -> Cursor Themes
There you can set the size of the cursor.
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Unfortunately, I’m using Gnome (not sure which) on one or two, and xfce on the rest.
If those above do not suit, search on http://gnome-look.org/ and see if you find a cursor that is better.